| Tag | Content |
|---|
| CPLM ID | CPLM-004591 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Potassium voltage-gated channel subfamily A member 6 |
Protein Synonyms/Alias | RCK2; Voltage-gated potassium channel subunit Kv1.6; Voltage-gated potassium channel subunit Kv2 |
Gene Name | Kcna6 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 499 | ATDNGLGKPDFAEAS | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. |
Sequence Annotation | MOTIF 423 428 Selectivity filter (By similarity).
MOTIF 527 529 PDZ-binding (Potential).
MOD_RES 8 8 Phosphothreonine (By similarity).
MOD_RES 222 222 Phosphoserine; by CK2 (Potential).
MOD_RES 512 512 Phosphoserine; by PKA (Probable).
MOD_RES 528 528 Phosphothreonine; by PKA (Potential).
LIPID 286 286 S-palmitoyl cysteine (Potential).
CARBOHYD 46 46 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Glycoprotein; Ion channel; Ion transport; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 530 AA |
Protein Sequence | MRSEKSLTLA APGEVRGPEG EQQDAGEFQE AEGGGGCCSS ERLVINISGL RYETQLRTLS 60
LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY QSGGRLRRPV NVPLDIFMEE 120
IRFYQLGDEA LAAFREDEGC LPEGGEDEKP LPSQPFQRQV WLLFEYPESS GPARGIAIVS 180
VLVILISIVI FCLETLPQFR ADGRGGSNEG SGTRMSPASR GSHEEEDEDE DSYAFPGSIP 240
SGGLGTGGTS SFSTLGGSFF TDPFFLVETL CIVWFTFELL VRFSACPSKA AFFRNIMNII 300
DLVAIFPYFI TLGTELVQRH EQQPVSGGSG QNRQQAMSLA ILRVIRLVRV FRIFKLSRHS 360
KGLQILGKTL QASMRELGLL IFFLFIGVIL FSSAVYFAEA DDVDSLFPSI PDAFWWAVVT 420
MTTVGYGDMY PMTVGGKIVG SLCAIAGVLT IALPVPVIVS NFNYFYHRET EQEEQGQYTH 480
VTCGQPTPDL KATDNGLGKP DFAEASRERR SSYLPTPHRA YAEKRMLTEV 530 |
Gene Ontology | GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro. GO:0005251; F:delayed rectifier potassium channel activity; IBA:RefGenome. GO:0051260; P:protein homooligomerization; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |