CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011566
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protocadherin-1 
Protein Synonyms/Alias
 Cadherin-like protein 1; Protocadherin-42; PC42 
Gene Name
 PCDH1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
894QAGKKETKDLYAPKPubiquitination[1]
900TKDLYAPKPSGKASKubiquitination[1]
920GKKSKSPKPVKPVEDubiquitination[1]
923SKSPKPVKPVEDEDEubiquitination[1]
935EDEAGLQKSLKFNLMubiquitination[1]
938AGLQKSLKFNLMSDAubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 May be involved in cell-cell interaction processes and in cell adhesion. 
Sequence Annotation
 DOMAIN 58 168 Cadherin 1.
 DOMAIN 169 280 Cadherin 2.
 DOMAIN 281 387 Cadherin 3.
 DOMAIN 396 506 Cadherin 4.
 DOMAIN 507 612 Cadherin 5.
 DOMAIN 613 715 Cadherin 6.
 DOMAIN 718 844 Cadherin 7.
 MOD_RES 918 918 Phosphoserine.
 MOD_RES 949 949 Phosphoserine.
 MOD_RES 962 962 Phosphoserine.
 MOD_RES 984 984 Phosphoserine.
 CARBOHYD 305 305 N-linked (GlcNAc...).
 CARBOHYD 403 403 N-linked (GlcNAc...) (Potential).
 CARBOHYD 618 618 N-linked (GlcNAc...) (Potential).
 CARBOHYD 662 662 N-linked (GlcNAc...) (Potential).
 CARBOHYD 813 813 N-linked (GlcNAc...).
 CARBOHYD 818 818 N-linked (GlcNAc...).  
Keyword
 Alternative splicing; Calcium; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1060 AA 
Protein Sequence
MDSGAGGRRC PEAALLILGP PRMEHLRHSP GPGGQRLLLP SMLLALLLLL APSPGHATRV 60
VYKVPEEQPP NTLIGSLAAD YGFPDVGHLY KLEVGAPYLR VDGKTGDIFT TETSIDREGL 120
RECQNQLPGD PCILEFEVSI TDLVQNGSPR LLEGQIEVQD INDNTPNFAS PVITLAIPEN 180
TNIGSLFPIP LASDRDAGPN GVASYELQAG PEAQELFGLQ VAEDQEEKQP QLIVMGNLDR 240
ERWDSYDLTI KVQDGGSPPR ASSALLRVTV LDTNDNAPKF ERPSYEAELS ENSPIGHSVI 300
QVKANDSDQG ANAEIEYTFH QAPEVVRRLL RLDRNTGLIT VQGPVDREDL STLRFSVLAK 360
DRGTNPKSAR AQVVVTVKDM NDNAPTIEIR GIGLVTHQDG MANISEDVAE ETAVALVQVS 420
DRDEGENAAV TCVVAGDVPF QLRQASETGS DSKKKYFLQT TTPLDYEKVK DYTIEIVAVD 480
SGNPPLSSTN SLKVQVVDVN DNAPVFTQSV TEVAFPENNK PGEVIAEITA SDADSGSNAE 540
LVYSLEPEPA AKGLFTISPE TGEIQVKTSL DREQRESYEL KVVAADRGSP SLQGTATVLV 600
NVLDCNDNDP KFMLSGYNFS VMENMPALSP VGMVTVIDGD KGENAQVQLS VEQDNGDFVI 660
QNGTGTILSS LSFDREQQST YTFQLKAVDG GVPPRSAYVG VTINVLDEND NAPYITAPSN 720
TSHKLLTPQT RLGETVSQVA AEDFDSGVNA ELIYSIAGGN PYGLFQIGSH SGAITLEKEI 780
ERRHHGLHRL VVKVSDRGKP PRYGTALVHL YVNETLANRT LLETLLGHSL DTPLDIDIAG 840
DPEYERSKQR GNILFGVVAG VVAVALLIAL AVLVRYCRQR EAKSGYQAGK KETKDLYAPK 900
PSGKASKGNK SKGKKSKSPK PVKPVEDEDE AGLQKSLKFN LMSDAPGDSP RIHLPLNYPP 960
GSPDLGRHYR SNSPLPSIQL QPQSPSASKK HQVVQDLPPA NTFVGTGDTT STGSEQYSDY 1020
SYRTNPPKYP SKQVGQPFQL STPQPLPHPY HGAIWTEVWE 1060 
Gene Ontology
 GO:0005911; C:cell-cell junction; TAS:ProtInc.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0007156; P:homophilic cell adhesion; IEA:InterPro.
 GO:0007399; P:nervous system development; TAS:ProtInc. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR020894; Cadherin_CS.
 IPR013164; Cadherin_N.
 IPR013585; Protocadherin. 
Pfam
 PF00028; Cadherin
 PF08266; Cadherin_2
 PF08374; Protocadherin 
SMART
 SM00112; CA 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.