CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036400
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Regulating synaptic membrane exocytosis 2 
Protein Synonyms/Alias
 Regulating synaptic membrane exocytosis protein 2 
Gene Name
 Rims2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
815RPRNPYVKIYFLPDRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1572 AA 
Protein Sequence
MSAPLGPRGR PAPTPAASQP PPQPEMPDLS HLTEEERKII LAVMDRQKKE EEKEQSVLKK 60
LHQQFEMYKE QVKKMGEESQ QQQEQKGDAP TCGICHKTKF ADGCGHNCSY CQTKFCARCG 120
GRVSLRSNKV MWVCNLCRKQ QEILTKSGAW FYNSGSNTLQ QPDQKVPRGL RNEEAPQEKK 180
AKLHEQPQFQ GAPGDLSVPA VEKGRAHGLT RQDTIKNGSG VKHQIASDMP SDRKRSPSVS 240
RDQNRRYEQS EEREDYSQYV PSDGTMPRSP SDYADRRSQR EPQFYEEPGH LNYRDSNRRG 300
HRHSKEYIVD DEDVESRDEY ERQRREEEYQ ARYRSDPNLA RYPVKPQPYE EQMRIHAEVS 360
RARHERRHSD VSLANAELED SRISLLRMDR PSRQRSVSER RAAMENQRSY SMERTREAQG 420
QSSYPQRTSN HSPPTPRRSP IPLDRPDMRR ADSLRKQHHL DPSSAVRKTK REKMETMLRN 480
DSLSSDQSES VRPPPPRPHK SKKGGKMRQV SLSSSEEELA STPEYTSCDD VELESESVSE 540
KGDSQKGKRK TSEQGVLSDS NTRSERQKKR MYYGGHSLEE DLEWSEPQIK DSGVDTCSST 600
TLNEEHSHSD KHPVTWQPSK DGDRLIGRIL LNKRLKDGSV PRDSGAMLGL KVVGGKMTES 660
GRLCAFITKV KKGSLADTVG HLRPGDEVLE WNGRLLQGAT FEEVYNIILE SKPEPQVELV 720
VSRPIGDIPR IPDSTHAQLE SSSSSFESQK MDRPSISVTS PMSPGMLRDV PQFLSGQLSI 780
KLWFDKVGHQ LIVTILGAKD LPSREDGRPR NPYVKIYFLP DRSDKNKRRT KTVKKTLEPK 840
WNQTFIYSPV HRREFRERML EITLWDQARV REEESEFLGE ILIELETALL DDEPHWYKLQ 900
THDVSSLPLP RPSPYLPRRQ LHGESPTRRL QRSKRISDSE VSDYDCEDGV GVVSDYRHNG 960
RDLQSSTLSV PEQVMSSNHC SPSGSPHRVD VIGRTRSWSP SAPPPQRNVE QGHRGTRATG 1020
HYNTISRMDR HRVMDDHYSS DRDSHFLTLP RSRHSQTIDH HHRDGRDCEA ADRQPYHRSR 1080
STEQRPLLER TTTRSRSSER PDTNLMRSMP SLMTGRSAPP SPALSRSHPR TGSVQTSPSS 1140
TPGTGRRGRQ LPQLPPKGTL ERSAMDIEER NRQMKLNKYK QVAGSDPRLE QDYHSKYRSG 1200
WDPHRGADTV STKSSDSDVS DVSAVSRTSS ASRFSSTSYM SVQSERPRGN RKISVFTSKM 1260
QNRQMGVSGK NLTKSTSISG DMCSLEKNDG SQSDTAVGAL GTSGKKRRSS IGAKMVAIVG 1320
LSRKSRSASQ LSQTEGGGKK LRSTVQRSTE TGLAVEMRNW MTRQASREST DGSMNSYSSE 1380
GNLIFPGVRL ASDSQFSDFL DGLGPAQLVG RQTLATPAMG DIQVGMMDKK GQLEVEIIRA 1440
RGLVVKPGSK TLPAPYVKVY LLDNGVCIAK KKTKVARKTL EPLYQQLLSF EESPQGRVLQ 1500
IIVWGDYGRM DHKSFMGVAQ ILLDELELSN MVIGWFKLFP PSSLVDPTLA PLTRRASQSS 1560
LESSTGPSYS RS 1572 
Gene Ontology
 GO:0044325; F:ion channel binding; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0017156; P:calcium ion-dependent exocytosis; IDA:MGI.
 GO:0048791; P:calcium ion-dependent exocytosis of neurotransmitter; IGI:MGI.
 GO:0019933; P:cAMP-mediated signaling; IDA:MGI.
 GO:0030073; P:insulin secretion; IDA:MGI.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0017157; P:regulation of exocytosis; IMP:MGI.
 GO:0042391; P:regulation of membrane potential; IDA:MGI. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR001478; PDZ.
 IPR010911; Rab-bd_domain.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00168; C2
 PF00595; PDZ 
SMART
 SM00239; C2
 SM00228; PDZ 
PROSITE
 PS50004; C2
 PS50106; PDZ
 PS50916; RABBD
 PS50178; ZF_FYVE 
PRINTS