UniProt Accession

 CNN1_MOUSE; Q08091 

Genbank Protein ID

 Z19542; L49022; L49022; U28932; U40351; U38930; U40348; U40349; U40350 

Genbank Nucleotide ID

 CAA79602.1; AAB01453.1; AAB01452.1; AAC52448.1; AAC52353.1; AAC52353.1; AAC52353.1; AAC52353.1; AAC52353.1 

Protein Name

 Calponin-1 

Protein Synonyms/Alias

 Basic calponin; Calponin H1, smooth muscle 

Gene Name

 Cnn1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
19	YGLSAEVKNKLAQKY	ubiquitination	[1]
143	NKVNVGVKYAEKQER	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. 

Sequence Annotation

 DOMAIN 28 131 CH.
 REPEAT 164 189 Calponin-like 1.
 REPEAT 204 229 Calponin-like 2.
 REPEAT 243 268 Calponin-like 3.
 MOD_RES 170 170 Phosphothreonine; by ROCK2 (By
 MOD_RES 175 175 Phosphoserine; by ROCK2 (By similarity).
 MOD_RES 180 180 Phosphothreonine; by ROCK2 (By
 MOD_RES 184 184 Phosphothreonine; by ROCK2 (By
 MOD_RES 259 259 Phosphothreonine; by ROCK2 (By  

Keyword

 Actin-binding; Alternative splicing; Calmodulin-binding; Complete proteome; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 297 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; ISO:MGI.
 GO:0031032; P:actomyosin structure organization; IEA:InterPro. 

Interpro

 IPR001997; Calponin.
 IPR000557; Calponin_repeat.
 IPR001715; CH-domain.
 IPR003096; SM22_calponin. 

Pfam

 PF00402; Calponin
 PF00307; CH 

SMART

 SM00033; CH 

PROSITE

 PS01052; CALPONIN_1
 PS51122; CALPONIN_2
 PS50021; CH 

PRINTS

 PR00889; CALPONIN.
 PR00888; SM22CALPONIN.