CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022722
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cathepsin F 
Protein Synonyms/Alias
  
Gene Name
 Ctsf 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
367ELSRNENKIAAWLAQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. 
Sequence Annotation
 ACT_SITE 273 273 By similarity.
 ACT_SITE 409 409 By similarity.
 ACT_SITE 429 429 By similarity.
 CARBOHYD 35 35 N-linked (GlcNAc...) (Potential).
 CARBOHYD 138 138 N-linked (GlcNAc...) (Potential).
 CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
 CARBOHYD 345 345 N-linked (GlcNAc...) (Potential).
 CARBOHYD 356 356 N-linked (GlcNAc...) (Potential).
 CARBOHYD 418 418 N-linked (GlcNAc...) (Potential).
 DISULFID 270 311 By similarity.
 DISULFID 304 344 By similarity.
 DISULFID 402 450 By similarity.  
Keyword
 Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Protease; Reference proteome; Signal; Thiol protease; Zymogen. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 462 AA 
Protein Sequence
MAPLLQLLWL LTLLSTVALS PVPAKPWADD EQAWNLSSQE LLAPARFALD MYNYGRAAGT 60
RAVLGAVRGR VRRAGQGSLF SLEATLEEPP CNDPLVCPLP ETKKTVLCSF EVLEELKEHL 120
LLRRDCSPVN AKVTEFRNAT FSSFLPLLDK DPLPQDFSVK MAPLFKDFMT TYNRTYESRE 180
EAQWRLTVFA RNMIRAQKIQ ALDRGTAQYG ITKFSDLTEE EFHTIYLNPL LQKESGRKMS 240
PAKSINDLAP PEWDWRKKGA VTEVKNQGMC GSCWAFSVTG NVEGQWFLNR GTLLSLSEQE 300
LLDCDKVDKA CLGGLPSNAY AAIKNLGGLE TEDDYGYQGH VQTCNFSAQM AKVYINDSVE 360
LSRNENKIAA WLAQKGPISV AINAFGMQFY RHGIAHPFRP LCSPWFIDHA VLLVGYGNRS 420
NIPYWAIKNS WGSDWGEEGY YYLYRGSGAC GVNTMASSAV VN 462 
Gene Ontology
 GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
 GO:0008234; F:cysteine-type peptidase activity; ISS:MGI.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR000169; Pept_cys_AS.
 IPR025660; Pept_his_AS.
 IPR013128; Peptidase_C1A.
 IPR000668; Peptidase_C1A_C.
 IPR013201; Prot_inhib_I29. 
Pfam
 PF08246; Inhibitor_I29
 PF00112; Peptidase_C1 
SMART
 SM00848; Inhibitor_I29
 SM00645; Pept_C1 
PROSITE
 PS00640; THIOL_PROTEASE_ASN
 PS00139; THIOL_PROTEASE_CYS
 PS00639; THIOL_PROTEASE_HIS 
PRINTS
 PR00705; PAPAIN.