CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035182
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Prkdc 
Protein Synonyms/Alias
  
Gene Name
 Prkdc 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
555EKSPVNSKSLFKRLYacetylation[1]
3380KVPADLLKRAFVKMSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3624 AA 
Protein Sequence
DVESRSENRW ASEEVRMGRW KVPTYKDYVD LFQNLLGCDQ MADFILGDET FLFVNSSLKS 60
LNHLLYDEFI RSVLKIVEKL DLTLEKQTTG EQEDERTADV WVIPTSDPAA NLHPIKPNDF 120
SAFINLVEFC REILPKKQVS FFEPWVYSFA YELILQSTRL PLISGFYKLL SIAVKNARKI 180
KYFEGVSPKC LKHSPENTEK HSCFALFAKF GKEVSVKMKQ YKDELLASCL TFVLSLPPDI 240
IKLDVRAYVP ALQMAFKLGL SHLPLAEIGL HALKEWSVHI DKSIMQPYYK DIVPCLDGYL 300
NTSTLSDETK SHWEVSALSR AARKGFNRDV VKLLKRTRNV TSDEALSLEE IRIRVVQILG 360
SLGGQINKNL ITATSGERMK KYVAWDREKR LSFAVPFREM KPVIYLDVFL PRVTELALSA 420
SDRQTKVAAC ELLHSMVMFM LGRATQMPEG QGLPPMYQLY KHMFPVLLKL ACDVDQVTRQ 480
LYEPLVMQLI HWFTNNKKFE SQDTVALLEA ILDGIVDPVD STLRDFCGQC VQEFLKWSIK 540
QTTPQQQEKS PVNSKSLFKR LYSLALHPNA FKRLGAALAF NHIYKEFREE GSLVEQFVFE 600
ALVTYMESLA LAHADEKSLG TIQQCCDAID HLRRIIEKKY ISLNKAKKRR LPRGFPPLTS 660
LCLLDLVKWL FAHCGRPQTE CRHKSIELFY KFVPLLPGNK SPSLWLRDLI KAEGISFLIN 720
TFEGGASSSG QPSGILAQPT LLHLQGPVSL RGMLQWLDHL LAALECYNTF IEEKTVQVQE 780
VLGTEVQSSL LKSVAFFLES IATCDARTVE QRFGTGLTGP PSVQEEEKYN YSKCTVLVRI 840
MEFTTTLLVT FPEDCKLLEK DLCNTKLMKV LVKMLCEPLS IGFNIGDVQV MNHLPSICVN 900
LLKALRKSPY RDKLETHLKE KVTAQSVEEL CAINLCSSAA CQERTKLLSL LSACKQLHKA 960
GFSHIISASQ STALNHSIGM RLLSLVYNGI APAQEKQYLQ SLDPSCKSLA SGLLELAFAF 1020
GGLCEHLVSL LLNSSMLSTQ YLGSSQRNIS FSHGEYFYSL FPEVINTELL KSLDVTVSRL 1080
LESSSDNPKM VSTILNGMLD MSFRDRAVQK HQGLKLATAI LQNWRKCDSW WAPDSAPESK 1140
TTVLSLLAKM LQIDSTLSFD TNHSSFSEIF TTYANLLADT KLGLHLKGQA VILLPFFTRV 1200
TEDRLGDLKH ILEKFIVLNF PMKSDEFPPD SLKYNNYVDC MKKFLDALEL SQSPMLLQLM 1260
TDILCREQQH IMEELFQTTF KRIARRSPCV TQLNLLESVY TMFRKGGLLS DVTQAFVDRS 1320
LLTLLWHCDL DTLKEFFSRI VVEAIDVLKS RFTKLNDTFD TQITKKMCYY KMLAVMYSRL 1380
LKDDVHSKES KINQAFQGSC VAEGNELTKT LLKLCHDAFT ENMAGESQLL EKRRLYHCAA 1440
YNCAISLISR VFNELKFYQG FLFSEKPEKN LFIFENLIDL KRCYTFPIEV EVPMERKKKY 1500
VEIRKEARDA ANGASGNPRY MSSLSYLTES SLSEEMSQFD FSTGVQSYSY SSQDRKPTTG 1560
HFQRREHQDS MAQDDIIELE MDELNQHECM APMTSLIKHM QRNVIAPKGQ EGSISKDLPP 1620
WMKFLHDKLE NASVSLNIRL FLAKLVINTE EVFRPYAKHW LGPLLQLAVC ENIGEGIHYM 1680
IVEIVATILS WTGLATPTGV PKYEVLANRL LYFLMKYVFH PKRAVFRHNL EIIKTLVECW 1740
KECLSIPYRL IFEKFSNKDP NSKDNSVGIQ LLGIVVANNL PPYDLKGDIT SAMYFEALVN 1800
NMSFVKYKEV YAAAAEVLGL ILQHVTERKH VIAESVYELV VKQLKQHQNT MEDKFIVCLN 1860
KIVKGFPPLA DRFLNALFFL LPKFHGVMKT LCLEVVLCRA EAITGLYLQL KSKDFLQVMR 1920
HRDDERQKVC LDIIYKMVAK LKPTELRELL NPVVEFVSHP SPTCREQMYN ILMWIHDNYR 1980
DPESQMDEDS QEIFKLAKDV LIQGLIDENL GLQLIIRNFW SHETRLPSNT LDRLLALNSL 2040
YSPKIEVHFL SLATNFLLEM TRMSPDYLNP IFEHPLSECE FQEYTIDPDW RFRSTVLTPM 2100
FIETQAFPST LNTQTQEGSP SDRRQKPGQV RATQQQYDFT PTQTSVERSS FDWLTGSSID 2160
LMADHTVFSS ESLSSSLLFS HKKSEKSQRV SWKSVGPDFG TKKLGLPGDE VDNQVKSGTH 2220
SQTEILRLRR RFLKDQEKLS LLYAKRGLME QKLEKDIKSE LKMKQDAQVV LYRSYRHGDL 2280
PDIQIQHSSL ITPLQAVAQK DPIIAKQLFS SLFSGILKEM HKFRTTSEKN IIIQNLLQDF 2340
NRFLNTTFLF FPPFVSCIQE ISCQHVDLLT LDPAAVRVGC LASLQQPGGI RLLEEALLHL 2400
LPKEPPTKRI RGKTCLPPDV LRWMELAKLY RSIGEYDVLH GIFSSELGTK QDTQNALLAE 2460
ARSDYFQAAN LYKEALNKLE WLDGEPTEAE KEFWEMASLD CYNNLSQWKE LEYRSTVNIG 2520
SENSLDLSKM WSKPFYQETY LPYVIRSKLK LLLQGEDNQS LLTFVDEAMH KELQQMVLEL 2580
QYSQELSLLY ILQDDIDRAT YYIKNAIQIF MQNYSSIDVL LYRSRLAKLQ SVQTLAEIEE 2640
FLNFIRKHGD LSSLGPLRRL LKTWTSRYPD TVTDPMHIWD DIITNRCFFL SKIEERLTVS 2700
PGDHSMSVDE DEDSFAREGS EPKEDAHHIL QSCRFTMKMK MIESSWKQNN FSLSMKLLKE 2760
MHKESKIRES WRMQWIHSFC QLNHCRSHTQ SPQEQVLTML KTITLLDESD ISNYLNKNIQ 2820
AFCDQNILLG TSCRIMADAL SREPACLSGL EKSKTESIFA LSGSNTENTE RVISGLYQRA 2880
FHHLSMAVQS AEEETQLSCW GHEAAAERAH AYMTLVGFCD QQLRKVEESA SSKNSTELEG 2940
YPALVVEKML RALKLNSSEA RLKFPRLLQI IEQYPEETVN IIIKEISSIP CWQFIGWIGH 3000
MVALLDKEEA IAVQHTVEEI ADNYPQAIIY PFIISSESYS FQNTSSGHNN KAFVERIKSK 3060
LDQGGVIQGF INALDQLSNP DMLFKDWVND TKDELGKNPV NKKNIEKLYE RMYAALGDFR 3120
APGLGPFRRK FIQTFGKEFV KSFGNGGSKL LTMKLDEFRN ITDSLFVRMR KDSKLPGNLK 3180
EYSPWMSEFT VKSELEIPGQ YDGKSKPLPE YHVRISGFDE RVKVMVSLRK PKRIVIRGHD 3240
EKEYPFLVKG GEDLRQDQRI EQLFEVMNAI LSQDAACSQR NMQLRTYRVV PMTSRLGLIE 3300
WIENTMTLKD LLLSNMSQEE KVAYDSDSKA PIYDYRDWLI KVSGRSDVKG YTLMYSRANR 3360
TETVTAFRRR ENKVPADLLK RAFVKMSTSP EAFLALRSHF ASSHALLCIS HWLLGIGDRH 3420
LNNFMVAMET GSVIGIDFGH AFGSATQFLP IPELMPFRLT RQFISLMLPM KETGLVCTVM 3480
VHALRAFRSC AGLLTDTMEV FVKEPSFDWK GFEQTMLRKG GSWIQEINVT EKNWYPQHKI 3540
RYAKRKLAGA NPAVITCDEL RLGHEASPAF RSYVAVARGN KDYNIRAQEP ESRLSEETQV 3600
KCLVDQATDP NILGRTWEGW EPWM 3624 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
 GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR003152; FATC.
 IPR011009; Kinase-like_dom.
 IPR012582; NUC194.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR018936; PI3/4_kinase_CS.
 IPR003151; PIK-rel_kinase_FAT.
 IPR014009; PIK_FAT. 
Pfam
 PF02259; FAT
 PF02260; FATC
 PF08163; NUC194
 PF00454; PI3_PI4_kinase 
SMART
 SM00146; PI3Kc 
PROSITE
 PS51189; FAT
 PS51190; FATC
 PS00915; PI3_4_KINASE_1
 PS00916; PI3_4_KINASE_2
 PS50290; PI3_4_KINASE_3 
PRINTS