| Tag | Content |
|---|
| CPLM ID | CPLM-004406 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Guanine nucleotide-binding protein G(s) subunit alpha |
Protein Synonyms/Alias | Adenylate cyclase-stimulating G alpha protein |
Gene Name | GNAS |
Gene Synonyms/Alias | GNAS1 |
Created Date | July 27, 2013 |
Organism | Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chines |
NCBI Taxa ID | 10030 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 216 | ETKFQVDKVNFHMFD | ubiquitination | [1] |
|
Reference | [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA. Mol Cell Proteomics. 2012 May;11(5):148-59. [ PMID: 22505724] |
Functional Description | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. |
Sequence Annotation | NP_BIND 47 54 GTP (By similarity).
NP_BIND 198 204 GTP (By similarity).
NP_BIND 223 227 GTP (By similarity).
NP_BIND 292 295 GTP (By similarity).
METAL 54 54 Magnesium (By similarity).
METAL 204 204 Magnesium (By similarity).
BINDING 366 366 GTP; via amide nitrogen (By similarity).
MOD_RES 51 51 Phosphoserine (By similarity).
MOD_RES 352 352 Phosphoserine (By similarity).
LIPID 2 2 N-palmitoyl glycine (By similarity).
LIPID 3 3 S-palmitoyl cysteine (By similarity). |
Keyword | Cell membrane; GTP-binding; Lipoprotein; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Palmitate; Phosphoprotein; Transducer. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 394 AA |
Protein Sequence | MGCLGDSKTE DQRNEEKAQR EANKKIEKQL QKDKQVYRAT HRLLLLGAGE SGKSTIVKQM 60
RILHVNGFNG EGGEEDPQAA RSNSDGEKAT KVQDIKNNLK EAIETIVAAM SNLVPPVELA 120
NPENQFRVDY ILSVMNVPNF DFPPEFYEHA KALWEDEGVR ACYERSNEYQ LIDCAQYFLD 180
KIDVIKQADY VPSDQDLLRC RVLTSGIFET KFQVDKVNFH MFDVGGQRDE RRKWIQCFND 240
VTAIIFVVAS SSYNMVIRED NQTNRLQEAL NLFKSIWNNR WLRTISVILF LNKQDLLAEK 300
VLAGKSKIED YFPEFARYTT PEDATPEPGE DPRVTRAKYF IRDEFLRIST ASGDGRHYCY 360
PHFTCAVDTE NIRRVFNDCR DIIQRMHLRQ YELL 394 |
Gene Ontology | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0003924; F:GTPase activity; IEA:InterPro. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |