CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018672
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tetraspanin-2 
Protein Synonyms/Alias
 Tspan-2 
Gene Name
 Tspan2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
133EAYSDYLKDRARGNGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath (By similarity). 
Sequence Annotation
 CARBOHYD 139 139 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Direct protein sequencing; Glycoprotein; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 221 AA 
Protein Sequence
MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG TMKDLSSEDK SPEYFYVGLY 60
VLVGAGALMM TVGFFGCCGA MRESQCVLGS FFTCLLVIFA AEVTTGVFAF IGKDVAIRHV 120
QSMYEEAYSD YLKDRARGNG TLITFHSAFQ CCGKESSEQV QPTCPKELPG HKNCIDKIET 180
VISAKLQLIG IVGIGIAGLT IFGMIFSMVL CCAIRNSRDV I 221 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043209; C:myelin sheath; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara. 
Interpro
 IPR000301; Tetraspanin.
 IPR018499; Tetraspanin/Peripherin.
 IPR018503; Tetraspanin_CS.
 IPR008952; Tetraspanin_EC2. 
Pfam
 PF00335; Tetraspannin 
SMART
  
PROSITE
 PS00421; TM4_1 
PRINTS
 PR00259; TMFOUR.