| Tag | Content |
|---|
| CPLM ID | CPLM-023819 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nuclear factor erythroid 2-related factor 3 |
Protein Synonyms/Alias | NF-E2-related factor 3; NFE2-related factor 3; Nuclear factor, erythroid derived 2, like 3 |
Gene Name | NFE2L3 |
Gene Synonyms/Alias | NRF3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 77 | RAGHLHPKGRELDPA | ubiquitination | [1] | | 219 | EERVSAQKENSLQQN | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Activates erythroid-specific, globin gene expression. |
Sequence Annotation | DOMAIN 578 641 bZIP.
REGION 580 599 Basic motif (By similarity).
REGION 606 620 Leucine-zipper (By similarity). |
Keyword | Activator; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 694 AA |
Protein Sequence | MKHLKRWWSA GGGLLHLTLL LSLAGLRVDL DLYLLLPPPT LLQDELLFLG GPASSAYALS 60
PFSASGGWGR AGHLHPKGRE LDPAAPPEGQ LLREVRALGV PFVPRTSVDA WLVHSVAAGS 120
ADEAHGLLGA AAASSTGGAG ASVDGGSQAV QGGGGDPRAA RSGPLDAGEE EKAPAEPTAQ 180
VPDAGGCASE ENGVLREKHE AVDHSSQHEE NEERVSAQKE NSLQQNDDDE NKIAEKPDWE 240
AEKTTESRNE RHLNGTDTSF SLEDLFQLLS SQPENSLEGI SLGDIPLPGS ISDGMNSSAH 300
YHVNFSQAIS QDVNLHEAIL LCPNNTFRRD PTARTSQSQE PFLQLNSHTT NPEQTLPGTN 360
LTGFLSPVDN HMRNLTSQDL LYDLDINIFD EINLMSLATE DNFDPIDVSQ LFDEPDSDSG 420
LSLDSSHNNT SVIKSNSSHS VCDEGAIGYC TDHESSSHHD LEGAVGGYYP EPSKLCHLDQ 480
SDSDFHGDLT FQHVFHNHTY HLQPTAPEST SEPFPWPGKS QKIRSRYLED TDRNLSRDEQ 540
RAKALHIPFS VDEIVGMPVD SFNSMLSRYY LTDLQVSLIR DIRRRGKNKV AAQNCRKRKL 600
DIILNLEDDV CNLQAKKETL KREQAQCNKA INIMKQKLHD LYHDIFSRLR DDQGRPVNPN 660
HYALQCTHDG SILIVPKELV ASGHKKETQK GKRK 694 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. GO:0003713; F:transcription coactivator activity; TAS:ProtInc. GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |