| Tag | Content |
|---|
| CPLM ID | CPLM-012808 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Adenosylhomocysteinase |
Protein Synonyms/Alias | AdoHcyase; S-adenosyl-L-homocysteine hydrolase |
Gene Name | Ahcy13 |
Gene Synonyms/Alias | ahcY; CG11654 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 378 | ELWTKSDKYAVGVHV | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methinine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. |
Sequence Annotation | NP_BIND 157 159 NAD (By similarity).
NP_BIND 222 227 NAD (By similarity).
NP_BIND 299 301 NAD (By similarity).
BINDING 56 56 Substrate (By similarity).
BINDING 131 131 Substrate (By similarity).
BINDING 156 156 Substrate (By similarity).
BINDING 186 186 Substrate (By similarity).
BINDING 190 190 Substrate (By similarity).
BINDING 191 191 NAD (By similarity).
BINDING 243 243 NAD (By similarity).
BINDING 346 346 NAD (By similarity). |
Keyword | Complete proteome; Hydrolase; NAD; One-carbon metabolism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 432 AA |
Protein Sequence | MSKPSYKVAD ISLAEWGRKA IIIAENEMPG LMACRKKYGP SKPLKGARIT GCLHMTVQTA 60
VLIETLVELG AQVQWSSCNI FSTQDNAAAA IAATGVPVYA WKGETDEEYM WCIEQTLVFP 120
DGQPLNMILD DGGDLTNLVH EKFPQYLKNI KGLSEETTTG VHNLYKMFKE GRLGVPAINV 180
NDSVTKSKFD NLYGCRESLI DGIKRATDVM IAGKVCCVAG YGDVGKGCAQ ALKGFGGRVI 240
VTEVDPINAL QAAMEGYEVT TMEEASKEAS IFVTTTGCRD IITSVHLQQM PDDAIVCNIG 300
HFDIEIDVDW LNANAKEKVN VKPQVDRYTM QSGKHIILLA EGRLVNLGCA HGHPSFVMSN 360
SFTNQVLAQI ELWTKSDKYA VGVHVLPKIL DEEVASLHLE KLGVKLTKLT EKQATYLGVS 420
QTGPFKPDHY RY 432 |
Gene Ontology | GO:0004013; F:adenosylhomocysteinase activity; ISS:FlyBase. GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |