UniProt Accession

 STAU1_HUMAN; O95793; A8K9Z4; E1P5Y1; E1P608; Q5JW29; Q6GTM4; Q9H5B4; Q9H5B5; Q9Y3Q2 

Genbank Protein ID

 AF061939; AF061941; AF061938; AF061940; AJ132258; AY529074; AY546099; AL136601; AK292859; AL133174; AL133174; AL133174; CH471077; CH471077; CH471077; CH471077; CH471077; BC050432; BC095397 

Genbank Nucleotide ID

 AAD17531.1; AAD17533.1; AAD17530.1; AAD17532.1; CAB40082.1; AAS76636.1; AAS76637.1; CAB66536.1; BAF85548.1; CAC14084.1; CAC14085.1; CAI42820.1; EAW75669.1; EAW75671.1; EAW75672.1; EAW75673.1; EAW75674.1; AAH50432.1; AAH95397.1 

Protein Name

 Double-stranded RNA-binding protein Staufen homolog 1 

Protein Synonyms/Alias

  

Gene Name

 STAU1 

Gene Synonyms/Alias

 STAU 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
270	PRIKKKTKPIVKPQT	acetylation	[1]
299	AQIQQAKKEKEPEYT	ubiquitination	[2]
507	QGFQVEYKDFPKNNK	ubiquitination	[3]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. 

Sequence Annotation

 DOMAIN 72 162 DRBM 1.
 DOMAIN 184 251 DRBM 2.
 DOMAIN 286 354 DRBM 3.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 390 390 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Endoplasmic reticulum; Phosphoprotein; Reference proteome; Repeat; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 577 AA 

Protein Sequence

Gene Ontology

 GO:0010494; C:cytoplasmic stress granule; ISS:BHF-UCL.
 GO:0005875; C:microtubule associated complex; TAS:ProtInc.
 GO:0005791; C:rough endoplasmic reticulum; TAS:ProtInc.
 GO:0003725; F:double-stranded RNA binding; TAS:ProtInc.
 GO:0008298; P:intracellular mRNA localization; IEA:Compara. 

Interpro

 IPR001159; Ds-RNA-bd.
 IPR014720; dsRNA-bd-like_dom. 

Pfam

 PF00035; dsrm 

SMART

 SM00358; DSRM 

PROSITE

 PS50137; DS_RBD 

PRINTS