UniProt Accession

 ADT2_RAT; Q09073 

Genbank Protein ID

 D12771; BC059108 

Genbank Nucleotide ID

 BAA02238.1; AAH59108.1 

Protein Name

 ADP/ATP translocase 2 

Protein Synonyms/Alias

 ADP,ATP carrier protein 2; Adenine nucleotide translocator 2; ANT 2; Solute carrier family 25 member 5; ADP/ATP translocase 2, N-terminally processed 

Gene Name

 Slc25a5 

Gene Synonyms/Alias

 Ant2 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
10	DAAVSFAKDFLAGGV	acetylation	[1]
23	GVAAAISKTAVAPIE	acetylation	[1]
43	LQVQHASKQITADKQ	acetylation	[1]
147	RLAADVGKAGAEREF	acetylation	[1]
268	IARDEGGKAFFKGAW	acetylation	[1]
272	EGGKAFFKGAWSNVL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity). 

Sequence Annotation

 REPEAT 6 98 Solcar 1.
 REPEAT 111 201 Solcar 2.
 REPEAT 212 297 Solcar 3.
 MOTIF 235 240 Substrate recognition (By similarity).
 BINDING 80 80 Nucleotide (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylthreonine; in ADP/ATP translocase
 MOD_RES 23 23 N6-malonyllysine (By similarity).
 MOD_RES 42 42 Phosphoserine (By similarity).
 MOD_RES 52 52 N6,N6-dimethyllysine; alternate (By
 MOD_RES 52 52 N6-methyllysine; alternate (By
 MOD_RES 92 92 N6-malonyllysine (By similarity).
 MOD_RES 96 96 N6-malonyllysine (By similarity).
 MOD_RES 105 105 N6-acetyllysine (By similarity).
 MOD_RES 147 147 N6-malonyllysine (By similarity).
 MOD_RES 155 155 N6-acetyllysine (By similarity).
 MOD_RES 163 163 N6-acetyllysine (By similarity).
 MOD_RES 166 166 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Chromosome partition; Complete proteome; Direct protein sequencing; Membrane; Methylation; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 298 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:RGD.
 GO:0071817; C:MMXD complex; ISS:UniProtKB.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
 GO:1901029; P:negative regulation of mitochondrial outer membrane permeabilization; ISS:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
 GO:0055085; P:transmembrane transport; IEA:InterPro. 

Interpro

 IPR002113; Aden_trnslctor.
 IPR002067; Mit_carrier.
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 

Pfam

 PF00153; Mito_carr 

SMART

  

PROSITE

 PS50920; SOLCAR 

PRINTS

 PR00927; ADPTRNSLCASE.
 PR00926; MITOCARRIER.